Table 4.
Heamagglutination inhibition test with sera of Korean H5N8s infected ferrets.Antiserum againstRouteReciprocal HI titeraBuan2Gochang1A/broiler duck/Korea/Buan2/2014IN8040IT16080A/breeder duck/Korea/Gochang1/2014IN4080IT4080IN – intranasal, IT – intratracheal.aData are represented as mean.Full-size tableTable optionsView in workspaceDownload as CSV
Discussion
Outbreaks of the HPAI H5N8 in poultry farms were reported in Ireland in 1983 (Swayne, 2008) and in China throughout 2009 and 2010 (Zhao et al., 2013). Pathogenesis of H5N8 has been demonstrated only for Triacetyl Resveratrol such as chickens, turkeys, and ducks, but no human infection has been reported. The Korean H5N8 viruses isolated in 2014 were classified as highly pathogenic, possessing multiple basic amino acids at the cleavage site of the HA sequence: Gochang1 has LREKRRKR/GLF motifs and Buan2 has LRERRRKR/GLF motif (Lee et al., 2014) which showed L at position 9 with a deletion at position 4 of the HA cleavage site (Kang, 2015). Kang et al reported that Korean isolated H5N8 viruses were moderately pathogenic in wild mallard ducks and did not cause severe illness or death. However viral replication and shedding were greater in H5N8 infected mallards than in H5N1 infected mallards (Kang, 2015).
Heamagglutination inhibition test with sera of Korean H5N8s infected ferrets.Antiserum againstRouteReciprocal HI titeraBuan2Gochang1A/broiler duck/Korea/Buan2/2014IN8040IT16080A/breeder duck/Korea/Gochang1/2014IN4080IT4080IN – intranasal, IT – intratracheal.aData are represented as mean.Full-size tableTable optionsView in workspaceDownload as CSV
Discussion
Outbreaks of the HPAI H5N8 in poultry farms were reported in Ireland in 1983 (Swayne, 2008) and in China throughout 2009 and 2010 (Zhao et al., 2013). Pathogenesis of H5N8 has been demonstrated only for Triacetyl Resveratrol such as chickens, turkeys, and ducks, but no human infection has been reported. The Korean H5N8 viruses isolated in 2014 were classified as highly pathogenic, possessing multiple basic amino acids at the cleavage site of the HA sequence: Gochang1 has LREKRRKR/GLF motifs and Buan2 has LRERRRKR/GLF motif (Lee et al., 2014) which showed L at position 9 with a deletion at position 4 of the HA cleavage site (Kang, 2015). Kang et al reported that Korean isolated H5N8 viruses were moderately pathogenic in wild mallard ducks and did not cause severe illness or death. However viral replication and shedding were greater in H5N8 infected mallards than in H5N1 infected mallards (Kang, 2015).