Our study demonstrates the rich potential of harnessing biological components for engineered nanocommunication networks. We also demonstrate the importance of considering the role of noise in nanoscale systems, and we show that ONO-4059 function can actually be improved by tuning the level of noise. Furthermore, the use of nanofabricated structures enables the flexible, robust, and well-defined layout of communication channels.
Since our proposed system connects several different fields of research, we discuss background information and related work in Section 2. We describe our proposed system for stochastic resonance in Section 3 and detail materials and methods in Section 4. We present the model for our system in Section 5, and the modeling results in Section 6 demonstrate functional stochastic resonance for a variety of different conditions. In Section 7, we discuss these results and present concluding remarks.
2. Background and related work
Fig. 1. Platform components for proposed system. (a) Top left: E. coli cells harboring sender constructs express the I-protein (LasI here), which catalyzes synthesis of the AHL signal 3OC12HSL. Top right: E. coli cells harboring receiver constructs express the R-protein (LasR here) which forms a complex with the AHL signal that binds and activates a quorum sensing promoter pqsc (the rsaLpromoter here). Bottom: Experimental results of a disk of sender E. coli cells activating nearby droplets of receiver cells. (b) Receiver cells function in cell-free extract. (c) Cell mimic devices.Figure optionsDownload full-size imageDownload as PowerPoint slide
Since our proposed system connects several different fields of research, we discuss background information and related work in Section 2. We describe our proposed system for stochastic resonance in Section 3 and detail materials and methods in Section 4. We present the model for our system in Section 5, and the modeling results in Section 6 demonstrate functional stochastic resonance for a variety of different conditions. In Section 7, we discuss these results and present concluding remarks.
2. Background and related work
Fig. 1. Platform components for proposed system. (a) Top left: E. coli cells harboring sender constructs express the I-protein (LasI here), which catalyzes synthesis of the AHL signal 3OC12HSL. Top right: E. coli cells harboring receiver constructs express the R-protein (LasR here) which forms a complex with the AHL signal that binds and activates a quorum sensing promoter pqsc (the rsaLpromoter here). Bottom: Experimental results of a disk of sender E. coli cells activating nearby droplets of receiver cells. (b) Receiver cells function in cell-free extract. (c) Cell mimic devices.Figure optionsDownload full-size imageDownload as PowerPoint slide