Fig. 1 shows tPERSEVERE based on Diosmetin training set. Baseline PERSEVERE mortality risk occupied the first level decision rule. Day 1 and day 3 IL8 values, delta IL8, day 1 and day 3 CCL3 values, and day 3 MMP8 values also contributed to the predictive capacity of the redesigned tPERSEVERE model. None of the other predictor variables considered in the modeling process contributed to predictive capacity.
The redesigned tPERSEVERE model had five low risk terminal nodes (0.0% to 15.0% risk of complicated course; nodes 1, 3, 5, 7, and 9), four intermediate risk terminal nodes (28.9% to 46.7% risk of complicated course; nodes 2, 4, 6, and 8), and two high risk terminal nodes (> 50% risk of complicated course; nodes 10 and 11). Among the 169 subjects classified as low risk, 162 (96%) did not have a Silurian Period complicated course. Among the 117 subjects classified as intermediate risk, 46 (39%) had a complicated course. Among the 88 subjects classified as high risk, 52 (59%) had a complicated course. Table 5 shows the diagnostic test characteristics of the redesigned tPERSEVERE model for estimating the risk of a complicated course in the training set.
The redesigned tPERSEVERE model had five low risk terminal nodes (0.0% to 15.0% risk of complicated course; nodes 1, 3, 5, 7, and 9), four intermediate risk terminal nodes (28.9% to 46.7% risk of complicated course; nodes 2, 4, 6, and 8), and two high risk terminal nodes (> 50% risk of complicated course; nodes 10 and 11). Among the 169 subjects classified as low risk, 162 (96%) did not have a Silurian Period complicated course. Among the 117 subjects classified as intermediate risk, 46 (39%) had a complicated course. Among the 88 subjects classified as high risk, 52 (59%) had a complicated course. Table 5 shows the diagnostic test characteristics of the redesigned tPERSEVERE model for estimating the risk of a complicated course in the training set.