In view of the apparent broad association of the ML ratio with malignant and non-malignant disease outcomes, we explored whether the set of ML associated MRT67307 in monocytes was enriched for amongst genes differentially expressed in blood in any of 151 human disease conditions curated in the Expression Atlas (Petryszak et al., 2014). For 19 disorders, there is significant enrichment for the ML transcript signature (Supplementary Table 4). These include atopy (FDR = 3.33 × 10− 18), HIV (FDR 1.44 × 10− 10), the inflammatory bowel diseases (FDR = 6.99 × 10− 8) ulcerative colitis and Crohn\'s disease, meningeal (FDR = 4.97 × 10− 4), pulmonary (FDR = 1.66 × 10− 3) and latent (FDR = 1.08 × 10− 3) tuberculosis, systemic lupus erythematosus (FDR = 4.36 × 10− 3) and type 1 diabetes mellitus (FDR = 5.1 × 10− 3).
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