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Are Vincristine Worth The Money?

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锘� No significance was observed for resilience, measured as the number of shoots 10?months after the algal bloom (p=0.368). Similarly, stepwise multiple regression model also showed a significant, positive effect of allelic richness, but Wee1 signaling pathway inhibitor no influence of genotypic richness (p>0.05) or interaction between A and G, on survival measured 40?days after stress. The positive effect of allelic richness on survival was particularly strong following the diatom bloom (p=0.002, adjusted r2=0.22, Table?3, Figure?3), and only the interaction between allelic and genotypic richness showed a weak but significant relationship with the density of plots after 10?months recovery (p=0.020, adjusted r2=0.13; Table?3, Figure?3).

Finally, path analysis confirmed that the strong correlation between A and G inflated the apparent effect of G on seagrass www.selleckchem.com/products/lonafarnib-sch66336.html resistance to stress due to the hidden effect of changes in A with increasing G (Figure?2). Indeed, allelic richness had a stronger effect on resistance to disturbance, directly accounting for 25% of the variance (0.492) on the number of surviving shoots following stress, stronger therefore than genotypic diversity, which explained 15% of the variance (0.392; Figure?4). No significant effect was detected however on resilience, i.e. on shoot numbers 10?months after the algal bloom. Figure 4 Path analysis of allelic and genotypic richness. Path analysis showing the direct effects, equivalent to correlation coefficients, of allelic richness (A) and genotypic richness (G) on the resistance to perturbation (as the number of shoots having survived ...

Discussion Confounding effects of genotypic and allelic Vincristine richness This study makes a first attempt to test for the effect and interaction of allelic richness, a component of genetic diversity that has not been manipulated in previous experimental studies. The first important result is the relationship between genotypic and allelic richness at the low levels of genotypic richness typically used thus far in similar experiments (Figure?1). Indeed, results reported here show that it is unrealistic to dissociate the effect of allelic and genotypic richness on the whole experimental setup. Their high correlation prevented the setup of standardized levels of allelic richness for the three levels of genotypic richness used here (Figure?1b) and equal or equivalent to those manipulated in previous and similar studies.

The simulation of 1000 random combinations of allelic richness for each level of genotypic richness showed a clear correlation between these two parameters (r=0.904, p<0.001) that precludes the dissociation of their respective effects in a regular two-way ANOVA. Such a strong correlation is particularly expected when allelic richness levels are ignored in an experimental design, or in the absence of any deliberate attempt to reach comparable levels across different genotypic richness.</div>

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